Start Dating the origin of the ccr5 delta32

Dating the origin of the ccr5 delta32

It has been hypothesized that this allele was favored by natural selection during the Black Death. In the heterozygotes, this mutation strongly reduces the chance of HIV infection In the homozygotes, it completely protects against HIV infection.

Global gene expression analysis led to the identification of 11 differentially regulated genes.

Six of them are connected with mechanisms of immune response and control: LRG1, CXCR2, CCRL2, CD6, CD7, WD repeat domain, and CD30L.

A total of 540 healthy Jordanian subjects were randomly selected from all the geographic areas of Jordan.

12 individuals were found to be homozygous for CCR5 WT and 7 carried the CCR5-delta32 deletion heterozygously.

Nekhai1 1 Howard University, Washington, USA; 2 Saint Petersburg State Pediatric Medical University, Russia Resume.

We carried out an investigation with 54 blood samples of Nenets living in Yamalo-Nenets Autonomous District.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.