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While MDD is usually diagnosed according to the criteria laid out in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), psychologists and psychiatrists are cautioned in a footnote to "differentiate between normal grieving associated with a significant loss and a diagnosis of a mental disorder." In fact, the question of how to tell normal grief apart from pathological depression is still being debated and often raises concerns about misdiagnosing patients who might be wrongly medicated as a result.

In fact, one recent paper suggests that there can be as many as 1500 different symptom profiles that can meet the MDD diagnostic criteria, some of which don't have a single symptom in common.

Unfortunately, the current criteria are just too broad to be able to pin down exactly what major depression actually means and how it can be linked to any particular cause.

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It is up to the audience to infer ( if they are interested ) in what might have happened in their pasts.

Most of the brothels are not large, glitzy complexes, but rather small businesses in out-of-the-way parts of the state Sultry: Despite Mc Andrews' focus on the mundane parts of brothel life, there is often no getting around the sexuality inherent in the work that goes on inside the private rooms.

Priscilla for the camera poses in her teddy at Wild West Saloon Showing off: Dennis Hof, the owner of the Bunny Ranch and and three other brothels, plays up the sex and glamor in his clubs.

While scouting locations for the film, the Gilbey brothers used head cameras while climbing and exploring various locations.